Name: Sustine® 121
Brand: Novozymes

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1,3 specific lipase

Organic solvent friendly

Commercial applications

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Sustine® 121 is a 1,3 liquid lipase that works well with stereoselective hydrolysis and desymmetrization of esters.

Sustine® 121 is already being applied in the following commercial active pharmaceutical ingredients (APIs):

<ul><li>Pregabalin</li>
</ul>

1,3 specific lipase Organic solvent friendly Commercial applications

Benefits

Details

This product contains enzymes. While enzymes are safe to use in consumer applications, they need correct handling in working environments to ensure workers’ safety.

Indeed, repeated inhalation of enzyme dust or aerosols resulting from improper handling may induce sensitization and may cause allergic type 1 reactions in sensitized individuals.

Please follow the precautionary handling recommendations below:

<article class="align-right media media--type-image media--view-mode-ckeditor-medium"><div class="field field--name-field-media-image field--type-image field--label-hidden field__item"> <img src="https://cdn.novozymes.com/sites/default/files/styles/small_proportional/public/image/2023-03/safe_handling_icon.png.webp?itok=mCNXGSFp" width="120" height="121" alt="safe handling icon" loading="lazy" class="image-style-small-proportional" /></div>
 
 </article><ul><li>Avoid breathing dust/fume/gas/mist/vapors/spray</li>
	<li>Avoid contact with eyes, skin, or clothing</li>
	<li>In case of inadequate ventilation wear respiratory protection</li>
	<li>IF INHALED: Remove person to fresh air and keep comfortable for breathing</li>
	<li>If experiencing respiratory symptoms: Call a POISON CENTER or a doctor</li>
	<li>Store in a dry place. Store in a closed container</li>
	<li>Dispose of contents/containers in accordance with local regulations</li>
</ul>For recommendations on how to safely handle the enzyme product, please visit the <a href="https://cdn.novozymes.com/sites/default/files/document/2024-09/Novonesis_Working_with_enzymes.pdf">guide</a>.

Safe handling

Product features, details and benefits

Liquid

Stereoselective hydrolysis of esters, transesterification, and esterification of acids, and acylation of amines.

Mode of action

Physical form (recyclability)

Lipases

Sustine® 110 IM - Sustine® 140 - Base-1

Sustine® 121

Sustine® 121 works well in aqueous mediums, as well as in a wide range of organic solvents.

Can this product be used in both aqueous and organic solvent processes?

Sustine® 121 works well in low-water content.

Does this product work with low-water content?

Sustine® 121 is a water-soluble biocatalyst, where 2-3 aqueous extractions will remove all enzyme content.

How do I separate the enzyme from the product after reaction use?

Testing one of our products in your own production is the best way to experience all the benefits.