Proteases

Proteases catalyze proteolysis of polypeptides into smaller polypeptides, oligopeptides and amino acids. They do this by cleaving the peptide bonds through hydrolysis. This helps to catalyze stereoselective hydrolysis of amino esters and selective esters to synthesize new molecules in an environmentally-friendly process. Their unparalleled regio- and enantioselectivity, faster reaction rates and performance in milder reaction conditions make proteases ideal reaction catalysts.

• Synthesis of Vince Lactam: A key building block/intermediate for antiretroviral APIs (e.g. Abacavir, Bictegravir, Peramivir, etc.)
• Stereoselective hydrolysis of chiral intermediate for API (e.g. Brivaracetam ) synthesis
• Other general stereoselective hydrolysis of amino esters and selective esters